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近日，华西基础医学与法医学院刘肖珩教授团队在Bone Research发表原创研究论文，证实了基质囊泡来源的AnxA5在骨重塑中的重要作用，阐明了AnxA5通过促进基质囊泡与I型胶原的黏附，诱导骨前体细胞发生自噬和加速矿化预防骨丢失的新机制，为骨质疏松症的防治提供新策略。
西北工业大学生命学院骞爱荣教授团队主编《BONE CELL BIOMECHANICS, MECHANOBIOLOGY, AND BONE DISEASES》在爱思唯尔（ELSEVIER）出版集团正式出版（图）
骞爱荣 爱思唯尔 生物力学 骨疾病 骨细胞
2023/9/8
近日，由西北工业大学生命学院骞爱荣教授和胡丽芳副教授主编的英文专著《BONE CELL BIOMECHANICS, MECHANOBIOLOGY, AND BONE DISEASES》（中文译名：骨细胞生物力学、力学生物学和骨疾病）在国际知名出版社爱思唯尔（ELSEVIER）正式出版。
A Cornell-led collaboration has been awarded a five-year, $3.6 million grant from the National Institutes of Health to explore the ways that the gut microbiome – that mass of microorganisms inside us ...
2018年5月24日，国际学术期刊Bone Research在线发表了中国科学院生物化学与细胞生物学研究所邹卫国研究组的综述文章“Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts”。该文章系统阐述了成骨细胞...
Bone mineral density during pregnancy in women participating in a randomized controlled trial of vitamin D supplementation
bone mineral content bone mineral density cholecalciferol pregnancy vitamin D
2017/10/18
Background: Little is known about bone mineral density (BMD) during pregnancy. Advances in technology with lower radiation emissions by dual-energy X-ray absorptiometry instruments now permit the safe...
Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial
isoflavone bone turnover bioavailability probiotics osteopenia postmenopause equol bone density
2017/8/2
Background: Female age-related estrogen deficiency increases the risk of osteoporosis, which can be effectively treated with the use of hormone replacement therapy. However, hormone replacement therap...
Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial
isoflavone bone turnover bioavailability probiotics osteopenia postmenopause equol bone density
2017/8/2
Background: Female age-related estrogen deficiency increases the risk of osteoporosis, which can be effectively treated with the use of hormone replacement therapy. However, hormone replacement therap...
A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women
isoflavone bone estrogen deficiency osteopenia osteoporosis
2017/8/2
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...
A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women
isoflavone, bone, estrogen deficiency, osteopenia, osteoporosis
2017/8/2
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...
Challenges in defining the role of dietary protein in bone health
Challenges bone health dietary protein
2017/5/17
The systematic review of dietary protein and bone health and falls in the current issue of the Journal by Shams-White et al. (1) is thorough and timely. Their key findings are that dietary protein int...
Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation
protein bone health osteoporosis bone density diet
2017/4/12
Background: Considerable attention has recently focused on dietary protein’s role in the mature skeleton, prompted partly by an interest in nonpharmacologic approaches to maintain skeletal health in a...
Peripheral skeleton bone strength is positively correlated with total and dairy protein intakes in healthy postmenopausal women
bone fragility bone microstructure dairy products finite element analysis fracture risk HR-pQCT nutrition osteoporosis protein intake
2017/1/11
Background: Bone mineral content (BMC) and bone mineral density (BMD) are positively correlated with dietary protein intakes, which account for 1–8% of BMC and BMD variances. However, the relation bet...
Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health
bone density bone turnover half-life obesity vitamin D vitamin D–binding protein
2016/5/11
Background: The mechanism and clinical significance of low circulating 25-hydroxyvitamin D [25(OH)D] in obese people are unknown. Low total 25(OH)D may be due to low vitamin D–binding proteins (DBPs) ...
Role of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 in Ovarian Function and Their Importance in Mammalian Female Fertility — A Review
Cumulus Cells Granulosa Cells Oocyte Maturation Follicular Development Reproductive Efficiency TGF-β Superfamily
2015/12/26
Growth factors play an important role during early ovarian development and folliculogenesis, since they regulate the migration of germ cells to the gonadal ridge. They also act on follicle recruitment...
An integrated proteomics analysis of bone tissues in response to mechanical stimulation
bone stress biomarker discovery pathway analysis Tandem Mass Spectrometry
2015/3/5
Bone cells can sense physical forces and convert mechanical stimulation conditions into biochemical signals that lead to expression of mechanically sensitive genes and proteins. However, it is still p...