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Expression and Purification of the Recombinant Cytochrome P450 CYP141 Protein of Mycobacterium Tuberculosis as a Diagnostic Tool and Vaccine Production
Gene Expression Cytochrome P450 Enzyme System Mycobacterium Tuberculosis
2015/11/6
Background: Tuberculosis (TB) is regarded as a health problem worldwide, particularly in developing countries. Mycobacterium tuberculosis (M. tuberculosis) is the cause of this disease. Approximately ...
Cloning of the Recombinant Cytochrome P450 Cyp141 Protein of Mycobacterium tuberculosis as a Diagnostic Target and Vaccine Candidate
Cloning Cytochrome Mycobacterium Tuberculosis Diagnostic
2014/10/15
Background: Tuberculosis has been announced as a global emergency by World Health Organization and the second infectious agent of mortality worldwide. The general policy in the development of new vacc...
Impact of cytochrome P450 2C19*2 polymorphism on the clinical cardiovascular events after stent implantation in patients receiving clopidogrel of a southern Tunisian region
Clopidogrel CYP2C19*2 Polymorphism MACE Stent Thrombus
2013/1/11
Introduction: The concept of clopidogrel resistance, first described in biology is being strengthened by recent data from clinical epidemiology. The cardiologists have been sensitized to this concept ...
In vivo and in vitro induction of cytochrome P-450 synthesis in hyperoxia
animal mice Cytochrome P-450 Dark Adaptation Light Adaptation
2009/7/17
Exposure of dark- or light-adapted mice to 1--3 ATA oxygen for times ranging from 15 min to 4 h caused a progressive increase in P-450, which peaked and then decayed. The rate of decay appears to be i...
Synthesis of cytochrome P-450 in isolated liver cells during exposure to hyperoxia
animal mice cytochrome P-450 liver
2009/7/15
Mouse hepatocytes were separated within 15 min of the death of the animal. A method of determining cytochrome P-450 was developed and used to show that cells prepared quickly still contained normal le...
Cytochrome P-450 Reductase Activities in the Liver Microsomes of Diabetic Rats Induced With Some Chemical Solvents
Cytochrome P-450 Reductase Diabetic Rats Chemical Solvents
2009/7/2
Cytochrome P-450 Reductase enzyme is an important enzyme providing electrons to the microsomal cytochrome P-450 enzyme system metabolizing some endogenous subtances forming in the liver, drugs, chemic...
Common Cytochrome p4503A (CYP3A4 and CYP3A5) and Thiopurine S-Methyl Transferase (TPMT) Polymorphisms In Turkish Population
pharmacogenetics TPMT CYP3A4 CYP3A5
2009/6/22
Polymorphisms in the genes encoding cytochrome p450 (CYP) and thiopurine S-methyl transferase (TPMT) enzymes catalyze the metabolic reactions of several drugs.These polymorphisms might be responsible ...
Evaluation of data in terms of two-dimensional random walk model：Interaction between NADH-cytochrome b5 reductase and cytochrome b5
two-dimensional random walk model NADH-cytochrome b5 cytochrome b5
2009/3/3
Normally, bimolecular reactions are analyzed in terms of the Smoluchowski theory. However, when one attempts to generalize this analysis to cases where diffusion proceeds in two other than in three ...
Gadolinium chloride suppresses styrene-induced cytochrome P450s expression in rat liver
Gadolinium chloride styrene-induced cytochrome P450s rat liver
2009/3/2
To assess the effect of gadolinium (Gd) on the expression of several forms of cytochrome P450 (P450s) and antioxidant enzymes, we treated rats with gadolinium chloride (25 mg as Gd/kg body weight) 4...
Abnormal Morphology of Spermatozoa in Cytochrome P450 17-hydroxylase/17, 20-lyase（CYP17）Deficient Mice
Gene deletion steroidogenesis mitochondria architecture fertility
2008/12/24
Cytochrome P450 17-hydroxylase/17, 20-lyase (CYP17) is crucial for cortisol and sex steroid biosynthesis. In a previous study we examined CYP17 function by generating mice with a targeted CYP17 d...
Cloning and Sequencing of cDNA Encoding for the Testis-Specific Fox（Vulpes Vulpes）Sperm Polypeptide Vb of the Cytochrome C Oxidase
Sperm antigen fox tissue specificity immunocontraception
2008/12/23
Identification of fox (Vulpes vulpes) sperm antigens was carried out to assess their interest as a potential target for a contraceptive vaccine. We report here the cloning and sequencing of fSP8, a ...
The pharmacogenetics of cytochrome P450 enzymes in personalized medicine
Personalized medicine Pharmacogenetics Cytochrome P450 CYP Individualized medicine
2007/10/25
Personalized medicine is partially enabled by in vitro diagnostics including pharmacogenomic, proteomic and other functional testing such as therapeutic drug management and toxicological testing. This...
The Cytochrome P450 System: Helping to Teach its Importance in Drug Metabolism and Drug Interactions
Cytochrome P450 System Teach its Importance Drug Metabolism Drug Interactions
1996/3/10
Knowledge of the cytochrome P450 system is important for the pharmacist because this enzyme participates in a number of drug interactions which may affect therapeutic outcomes and cause drug-induced t...