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Background: Interactions between eosinophils and monocytes after lipopolysaccharide inhalation are yet to be investigated. The mechanism of eosinophil activation induced by lipopolysaccharide in the p...
According to a logistic regression analysis adjusted for age, sex, family history, allergies, and wheezing at entry, young children with nasal eosinophil infiltration during acute RTI had a significan...
Accumulated eosinophils in the airways in asthma may directly react with HDM and produce IL-9 to further promote Th2-type immune responses. Protease-activated receptor 2, a ligand for serine proteases...
Background: To clarify the role of eosinophils in the pathogenesis of Kimura's disease and the values of measuring serum levels of eosinophil cationic protein (ECP) for monitoring disease activity mig...
Background: Recent reports suggest that small airway as well as large airway involvement in asthma is important. We investigate the therapeutic effects of a meter-dose inhaler of chrolofluorocarbon-be...
Eosinophils are the key effector cells for allergic inflammation. In order to clarify drugs which can regulate eosinophil function, we investigated the direct effect of pemirolast potassium (anti-alle...
We examined the functional heterogeneity of eosinophils from an adult T-cell leukemia (ATL) patient with eosinophilia. A 63-year-old man was admitted to our hospital because of lymphadenopathy. The le...
Platelet-activating factor (PAF) can activate various cellular functions, including degranulation in eosinophils. In the present study, we examined tyrosine phosphorylation of intracellular proteins i...
Eosinophil penetration across the basement membrane (BM) is thought to be dependent on the degradation of membrane components. In this process, matrix metalloproteinases (MMP) appear to be primarily r...
The findings show that intra- and extracellular properties of eosinophils can be analyzed with whole blood using PBQ fixation and OG treatment at a concentration of 7.4 mg/mL. Direct flowcytometric an...
Olopatadine hydrochloride (olopatadine; KW-4679), (Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride, is an antiallergic drug with selective and potent...
Interleukin-4 significantly enhanced SCF production, whereas tumor necrosis factor-α, interferon-γ and IL-1α showed suppressive effects on SCF pro-duction. When fibroblasts were cultured with IL-4 plu...
Respiratory syncytial virus (RSV) infection in early childhood is a risk factor for the development of wheezing, significant decreases in pulmonary function and increases in airway reactivity. Respira...
Analysis of the clinical data confirmed that the proportion of patients who showed greater than 60% improvement in symptoms (47 and 15%) and in rescue medication (79 and 10%) were significant for the ...
Background: Recently, a second prostaglandin D2 (PGD2) receptor, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), was identified. Because PGD2 was reported to have chemotac...

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