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Effects of KF19514, a Phosphodiesterase 4 and 1 Inhibitor, on Bronchial Inflammation and Remodeling in a Murine Model of Chronic Asthma
airway hyperresponsiveness airway remodeling asthma murine model PDE inhibitor
2009/6/11
Background: Phosphodiesterase 4 selective inhibitor may prevent airway inflammation and remodeling.
Objective: The aim of this study was to investigate the effects of KF19514, a phosphodiesterase 4 a...
Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase in cGMP metabolism in rabbit parotid acinar cells
Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase cGMP metabolism rabbit parotid acinar cells
2009/3/2
Muscarinic cholinergic receptor activation provokes cGMP formation in parotid acinar cells. We investigated the involvement of Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) in...
The Effects of Cyclic Adenine Nucleotides, Phosphodiesterase Inhibitors, and Cauda Epididymidal Fluid on the Motility of Rat Epididymal Spermatozoa
spermatozoa motility epididymal rat
2009/2/19
Experiments were performed to determine whether the rat epididymis secretes a "forward-motility" factor(s) similar to that found by others in the bovine epididymis. Lumen content of the rat caput ...
In Vitro Effect of Inhibin on Cyclic AMP-Phosphodiesterase Activity in Rat Testes
inhibin cyclic AMP-phosphodiesterase
2009/2/19
We have previously reported that incubation of testicular slices with inhibin in the presence of 6 x 10-8 M oFSH resulted in a dose-related reduction in accumulation of cyclic AMP due to a decreas...
Mechanism of stress-induced attenuation of the testicular response to gonadotropin：possible involvement of testicular opioids, a pertussis toxin-sensitive G-protein, and phosphodiesterase
stress-induced attenuation possible involvement testicular opioids pertussis toxin-sensitive G-protein
2009/2/16
This study examined the potential role of testicular opioids, a pertussis toxin (PT)-sensitive G-protein, and phosphodiesterase in mediating the inhibitory effect of immobilization stress on testi...
The cyclic GMP-specific phosphodiesterase inhibitor, sildenafil, stimulates human sperm motility and capacitation but not acrosome reaction
cyclic GMP-specific phosphodiesterase inhibitor sildenafil human sperm motility capacitation
2008/12/25
Capacitation is the series of transformations that spermatozoa undergo in the female genital tract in order to bind to the zona pellucida, initiate the acrosome reaction, and fertilize an egg. Cyc...
Optimizing Response To Phosphodiesterase Therapy：Impact of Risk-Factor Management
Phosphodiesterase Therapy Risk-Factor Management
2008/12/19
The key to successful treatment of any condition is to understand and treat its causes. The same is true for erectile dysfunction (ED). In the past several decades, the causes of ED have been elucidat...
Implication of Calmodulin-Dependent Phosphodiesterase Type 1 During Bovine Sperm Capacitation
Vinpocetine rolipram cyclic AMP in vitro fertilization motility
2008/12/18
Phosphodiesterases (PDEs) are enzymes that degrade cyclic nucleotides. The calcium-calmodulin dependent PDE type 1 (PDE 1) and the cyclic adenosine monophosphate (cAMP)-specific PDE type 4 (PDE 4) h...
Inhibition of tracheal smooth muscle cell proliferation by phosphodiesterase inhibitors
phosphodiesterase inhibitors proliferation tracheal smooth muscle cells
2006/3/29
Agents that increase intracellular cyclic 3',5'-adenosine monophosphate (cAMP), such as forskolin, prostaglandin (PG)E2, salbutamol and 8-bromo-cAMP, have been shownto inhibit the proliferation of air...
Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics
A-kinase anchoring protein (AKAP) β-arrestin phosphodiesterase 4 phosphodiesterase inhibitors Src tyrosine kinase
2006/1/19
Cyclic nucleotides are powerful signaling molecules and their sole means of removal is through the action of cyclic nucleotide phosphodiesterases (PDEs). Elevating levels of cAMP is beneficial in many...
The Phosphodiesterase 4 Inhibitor Prevents Antigen-induced Biphasic Nasal Obstruction in Brown Norway Rats
acoustic rhinometry allergic rhinitis BN rat nasal obstruction PDE inhibitor
2005/12/8
Background: Nasal obstruction is considered the most serious problem for patients with allergic rhinitis. We have previously established a model of nasal obstruction in guinea pigs. In the present stu...
Effects of phosphodiesterase inhibitors on secretions of human monokines
cilostazol interleukin-1β KF19514 monocytes phosphodiesterase inhibitor theophylline tumor necrosis factor α
2005/10/14
The purpose of this study was to evaluate the effect of newly developed selective phosphodiesterase (PDE) inhibitors, KF19514 (type I/IV) and cilostazol (type III), and theophylline on the secretions ...