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Receptors found on cell surfaces bind to hormones, proteins, and other molecules, helping cells respond to their environment. MIT chemists have now discovered how one of these receptors changes its sh...
A human neutralizing antibody targets the receptor binding site of SARS-CoV-2
Preventive medicine SARS-CoV-2 Viral infection
2020/5/26
An outbreak of the coronavirus disease 2019 (COVID-19)1–3, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)4 spread globally. Countermeasures are needed to treat and prevent ...
Key Residues of the Receptor Binding Motif in the Spike Protein of SARS-CoV-2 That Interact With ACE2 and Neutralizing Antibodies
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/5/17
Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotens...
Serum transferrin receptor concentration indicates increased erythropoiesis in Kenyan children with asymptomatic malaria
Iron deficiency anemia ferritin
2016/6/14
Serum transferrin receptor concentrations indicate
both erythropoietic activity and the deficit of functional iron in
the erythron. In contrast with serum ferritin concentrations,
serum transferrin...
Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes
bone mineral density elderly women Caffeine
2016/6/14
Our goals were 1) to compare in both a crosssectional
study and a 3-y longitudinal study the bone mineral
density (BMD) of postmenopausal women consuming high or
low amounts of caffeine and 2) to s...
Receptor-mediated signaling pathways: potential targets of modulation by dietary fatty acids
dietary fat tyrosine kinase protein kinase
2016/6/1
Extracellular signals are transmitted to intracellular
targets through many signal-transduction pathways. Each
signaling pathway is composed of a network of interacting signaling
molecules that reg...
Higher concentrations of serum transferrin receptor in children than in adults
Transferrin receptor ferritin iron
2016/5/30
The serum transferrin receptor (TfR) concentration
in adults is suggested to provide a sensitive measure of iron
depletion and together with the serum ferritin concentration to
indicate the entire ...
Expression and Clinical Significance of Tumor Necrosis Factor Receptor-Associated Factor 6 in Patients With Colon Cancer
Receptors Tumor Necrosis Factor Gene Expression Colonic Neoplasms
2016/1/26
Background: Tumor necrosis factor receptor-associated factor 6 (TRAF6) has been reported to be highly expressed in many tumor tissues, but it is still of value to detect its expression in patients wit...
Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons
NMDA receptor BDNF neurotrophins
2015/7/28
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions. However in pathol...
Serotonin receptor is involved in eczema and other itch conditions
Serotonin receptor eczema other itch conditions
2015/6/4
Dermatologists have long known that available treatments for chronic itch, including eczema, are simply not up to scratch. But scientists have now discovered a new gene that promotes itch, suggesting ...
Estrogen receptor involvement in the response of human keratinocytes to ultraviolet B irradiation
UVB Estrogen receptor Keratinocytes
2015/5/25
The signaling mechanisms involved in UVB-induced skin cancer are complex and although the scope of this work is inherently limited in focus, the findings may provide insight into how estrogen receptor...
The role of high mobility group box 1 and toll like receptor 4 in a rodent model of neuropathic pain
HMGB1 TLR4 Neuropathic Pain
2015/5/21
Neuropathic pain is a serious health problem that greatly impairs quality of life. The International Association for the Study of Pain (IASP) defines neuropathic pain as ‘pain arising as a direct cons...
THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/28
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/19
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
Lack of EGF receptor contributes to drug sensitivity of human germline cells
DNA damage epidermal growth factor receptor drug resistance
2014/12/12
Germline mutations have been associated with generation of various types of tumour. In this study, we investigated genetic alteration of germline tumours that affect the drug sensitivity of cells. Alt...