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Mechanism of LHRH-stimulated steroidogenesis in rat Leydig cells：lipoxygenase products of arachidonic acid may not be involved
LHRH-stimulated steroidogenesis rat Leydig cells lipoxygenase products arachidonic acid
2009/2/23
Luteinizing hormone releasing hormone agonist, [(imBzl)-DHis6,Pro9,NEt]-LHRH (LHRH-A), caused a two to threefold increase in in vitro testosterone (T) secretion by rat Leydig cells. This LHRH-A-indu...
Steroidogenesis and testosterone metabolism in cultured principal cells from the ram epididymis
Steroidogenesis testosterone metabolism cultured principal cells ram epididymis
2009/2/23
To determine if ram principal cells can synthesize or metabolize testosterone, or metabolize other steroids present in rete testis fluid, principal cells from the initial segment, central caput, and...
Induced hypoprolactinemia and testicular steroidogenesis in man
prolactin testes bromocriptine androgens
2009/2/20
The effects of short-term hypoprolactinemia on the pituitary-gonadal axis were evaluated in a group of patients with untreated prostatic carcinoma. Each patient was studied prior to and during 7-day...
Mechanism of action of gonadotropin-releasing hormone-stimulated Leydig cell steroidogenesis. II. Gonadotropin-releasing hormone stimulates phospholipid labeling
gonadotropin-releasing hormone Leydig cells steroidogenesis phospholipids
2009/2/20
To investigate mechanisms responsible for gonadotropin-releasing hormone (GnRH)-stimulated Leydig cell steroidogenesis, the effects of GnRH agonist [des-Gly10, (D-Ala6) GnRH] on phospholipid turnove...
Mechanism of action of gonadotropin-releasing hormone-stimulated Leydig cell steroidogenesis
gonadotropin-releasing hormone Leydig cells testosterone cAMP cAMP-dependent protein kinase nifedipine calcium
2009/2/20
The present study was designed to elucidate mechanisms responsible for gonadotropin-releasing hormone (GnRH)-stimulated testosterone formation. Purified Leydig cells from adult Sprague-Dawley rats...
Inhibition of Spermatogenesis and Steroidogenesis During Long-Term Treatment with hCG in the Rat
hCG spermatogenesis steroidogenesis
2009/2/19
The effects of chronic treatment with hCG (100 I.U.s.c. every second day) on testicular morphology, LH receptor levels and concentration of steroid intermediates of the 4 and 5 biosynthetic pathwa...
Further Studies on the Inhibitory Effect of [D-A1a6, des-Gly-NH210]LHRH Ethylamide on Spermatogenesis and Steroidogenesis in the Rat：Reversibility and Effect of Androgen Administration
antifertility spermatogenesis LHRH agonist
2009/2/18
Following the recent observation that chronic treatment with [D-Ala6, des-Gly-NH210]LHRH ethylamide, a potent LHRH agonist, leads to an almost complete degeneration of seminiferous tubules in the ra...
The cellular mechanisms of corticotropin-releasing hormone（CRH）-stimulated steroidogenesis in mouse Leydig cells are similar to those for LH
MA-b Progesterone testosterone
2009/2/17
Previous reports have demonstrated that corticotropin-releasing hormone (CRH) treatment of primary cultures of mouse Leydig cells and MA-10 mouse Leydig tumor cells results in a dose-dependent sti...
Effect of finasteride on human testicular steroidogenesis
Alopecia baldness 5cs-reductase 1 7-ketosteroid reductase
2009/2/16
We studied the testicular function and some androgen-mediated events in 22 males (16-30 years of age) with male pattern baldness that was treated with finasteride (10 mg once daily) for 2 years. Pat...
Effects of lipoprotein, equine luteinizing hormone, equine follicle-stimulating hormone, and equine prolactin on equine testicular steroidogenesis in vitro
Stallion testes steroid estrogen
2009/2/13
A stallion testicular cell incubation system was developed and used to investigate the regulation of steroidogenesis in stallion testes. Cells isolated from testes of 2- to 4-year-old stallions (n = 6...
Acute immobilization stress disrupts testicular steroidogenesis in adult male rats by inhibiting the activities of 17 alpha-hydroxylase and 17,20-lyase without affecting the binding of LH/hCG receptors
Stress rats testosterone 17a-hydroxylase
2009/2/12
We have investigated the effect of acute immobilization (3 hours) stress on testicular steroidogenesis in the adult rat. Immobilization did not alter plasma luteizing hormone (LH) levels, but plas...
Effect of finasteride on adrenal steroidogenesis in men
5a-Reductase inhibitor androgens dihydrotestosterone
2009/2/12
Finasteride, a 5 alpha-reductase inhibitor, does not bind to the androgen receptor and has no other known hormonal activity. To determine what effect, if any, it has on adrenal steroidogenesis, 10...
Inhibition of steroidogenesis in neonatal Leydig cells by unknown factor（s）present in spent media of androgen-treated cultured testicular cells from adult rats
Leydig cell 5a-dihydrotestosterone methyltrienolone
2009/2/12
Treatment of cultured testicular cells from adult rats with 5 alpha-dihydrotestosterone (DHT; 10(-6) M) or the synthetic androgen methyltrienolone (R1881; 10(-6) M) inhibited Leydig cell 3 beta-hy...
Testicular steroidogenesis in the aging brown Norway rat
Aging testis steroidogenesis Leydig cell rat
2009/2/12
In seeking an animal model of age-associated changes in the male reproductive tract, we examined the effects of age on the health and testicular steroidogenic activity of the Brown Norway rat, with ...
Oligotriche and quaking gene mutations. Phenotypic effects on mouse spermatogenesis and testicular steroidogenesis
Oligotriche quaking gene mutations Phenotypic effects mouse spermatogenesis testicular steroidogenesis
2009/2/10
The phenotypic actions of the oligotriche gene mutation on testicular function have not been elucidated, although it is known that male mice homozygous for the mutation are infertile. In the present...