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Association between Endothelial Selectin (E-Selectin) Gene Polymorphisms and E-Selectin Level with Visceral Leishmaniais, in an ARMS-PCR Based Study
Soluble E-selectin Gene Polymorphism Visceral Leishmaniasis Human ARMS-PCR Ser128Arg 554Leu/Phe
2009/12/18
Background: In the visceral leishmaniasis (VL), parasites reside in reticuluendothelial system, mainly in macrophages. Endothelial Selectin (E-selectin) might play an important role in leukocyte-endot...
本研究利用体外培养大鼠脑微血管内皮细胞(brain microvascular endothelial cells，BMEC)模型，探讨了血管紧张素(Ang)II对大鼠脑微血管内皮细胞表达E-selectin和VCAM-1的影响及其机制，并评价了新型AT1受体拮抗剂化合物EXP-2528对其的影响。采用RT-PCR和Western blotting分别检测大鼠脑微血管内皮细胞E-选择素(E-sel...