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What does it mean to target specific serum 25-hydroxyvitamin D concentrations in children and adolescents?
serum 25-hydroxyvitamin children adolescents
2016/10/18
The task of determining dietary requirements for vitamin D intake is one of the key unresolved issues in vitamin- and mineral-related nutrition. The complexities of issues, including determining intak...
The Effects of Glucagon-like Peptide-2 on the Tight Junction and Barrier Function in IPEC-J2 Cells through Phosphatidylinositol 3-kinase–Protein Kinase B–Mammalian Target of Rapamycin Signaling Pathway
Transepithelial Electrical Resistance Phosphatidylinositol 3-Kinase-Akt-mTOR Signaling Pathway
2016/5/20
Glucagon-like peptide-2 (GLP-2) is important for intestinal barrier function and regulation of tight junction (TJ) proteins, but the intracellular mechanisms of action remain undefined. The purpose of...
In Silico Target Prediction by Training Naive Bayesian Models on Chemogenomics Databases
Chemogenomics Databases Informatics
2015/5/26
The completion of Human Genome Project is seen as a gateway to the discovery of novel drug targets (Jacoby, Schuffenhauer, & Floersheim, 2003). How much of this information is actually translated into...
A Novel Network Biology Approach To Drug Target Selections
Network Biology Approach Drug Target Selections
2015/5/26
Conventional drug discovery focuses on single protein targets and follows a “sequence,
structure, and function” paradigm for selecting best protein targets to screen lead
chemical compounds. This es...
Differential Expression of miR-34c and Its Predicted Target Genes in Testicular Tissue at Different Development Stages of Swine
miR-34c PDGFRA Testicular Tissue Differential Expression
2015/5/19
To verified the target genes of miR-34c, bioinformatics software was used to predict the targets of miR-34c. Three possible target genes of miR-34c related to spermatogenesis and male reproductive dev...
Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells
apoptosis endocycling cells p53 protein
2015/1/7
Apoptotic cell death is an important response to genotoxic stress that prevents oncogenesis. It is known that tissues can differ in their apoptotic response, but molecular mechanisms are little unders...
Mitochondrial DNA Polymerase IB: Functional Characterization of a Putative Drug Target for African Sleeping Sickness
kDNA kinetoplast DNA mitochondria RNA interference trypanosoma brucei trypanosome
2014/12/10
Trypanosoma brucei and related parasites are causative agents of severe diseases that affect global health and economy. T. brucei is responsible for sleeping sickness in humans (African trypanosomiasi...
Target Recognition and Competitive Synaptogenesis in the Drosophila Giant Fiber System
competition Drosophila giant fiber guidance synaptogenesis
2014/12/10
The development of complex neural networks relies on a careful balance of environmental cues to guide and shape both ends of the eventual connection. However, the correct wiring of circuits whose comp...
Gold nanoparticles help target, quantify breast cancer gene segments in a living cell
Gold nanoparticles help target, quantify breast cancer gene segments in a living cell
2014/4/22
Alternative messenger RNA (mRNA) splicing is a fundamental process of gene regulation, and errors in RNA splicing are known to be associated with a variety of different diseases. However, there is cur...
01 May 2007，Manta rays are hard to miss —big, black and stretching up to seven metres wide, but scientists are still in the dark about the world’s largest ray.