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Folding and unfolding of a triple-branch DNA molecule with four conformational states
Nonequilibrium systems, single-molecule experiments,optical tweezers, DNA
2011/6/10
Single-molecule experiments provide new insights into biological processes hitherto not accessible by measurements performed on bulk systems. We report on a study of the kinetics of a triple-branch DN...
Stochastic emergence of multiple intermediates detected by single-molecule quasi-static mechanical unfolding of protein
single-molecule detection protein folding molecular force microscopy molecular dynamics energy landscape
2009/4/9
Experimental probing of a protein-folding energy landscape can be challenging, and energy landscapes comprising multiple intermediates have not yet been defined. Here, we quasi-statically unfolded sin...
Retention of local conformational compactness in unfolding of barnase; Contribution of end-to-end interactions within quasi-modules
module protein folding molecular dynamics simulation hierarchical folding denatured state
2007/5/25
To understand how protein reduces the conformational space to be searched for the native structure, it is crucial to characterize ensembles of conformations on the way of folding processes, in particu...