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The role of cell cycle progression and cyclin -dependent kinase 2 in thymocyte negative selection
T cells and thymus cells thymus self antigen cells
2014/12/11
Autoreactive, immature T cells (thymocytes) are deleted from the thymus during development by the process of negative selection. This mechanism occurs when the thymocyte, T cell receptor (TCR) recogni...
Cyclooxygenase and cyclic AMP -dependent protein kinase regulate actin organization and cell motility
Cells extracellular matrix cell signal cytoskeleton the cancer cells
2014/12/11
Cell adhesion to an extracellular matrix plays a critical role in many aspects of normal cell function. Cells display various modes of interaction with the extracellular matrix; they may attach and sp...
Activation of Src tyrosine kinase in microglia in the rat hippocampus following transient forebrain ischemia
Src Phosphorylation Transient forebrain ischemia Microglia
2004/3/31
o better understand the pathophysiological role of Src protein, a non-receptor protein tyrosine kinase of 60 kDa, in the ischemic brain,
we investigated the time course and regional distribution of a...
A NEUROPROTECTIVE ROLE OF EXTRACELLULAR SIGNAL-REGULATED KINASE IN N-ACETYL- O-METHYLDOPAMINE-TREATED HIPPOCAMPAL NEURONS AFTER EXPOSURE TO IN VITRO AND IN VIVO ISCHEMIA
ERK and CREB phosphorylation neuroprotection N-acetyl- O-methyldopamine selective neu-ronal injury oxygen-glucose deprivation transient forebrain ischemia
2003/3/31
In response to cerebral ischemia, neurons activate
survival/repair pathways in addition to death cascades. Acti-vation of cyclic AMP-response-element-binding protein
(CREB) is linked to neuroprotect...