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The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids
absorption ADME flavonoids genotype health metabolism microbiome
2017/11/23
At a population level, there is growing evidence of the beneficial effects of dietary flavonoids on health. However, there is extensive heterogeneity in the response to increased intake, which is like...
Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial
α-carboxyethyl hydroxychromanol α-CEHC α-carboxymethylbutyl
2017/1/11
Background: Vitamin E supplementation improves liver histology in patients with nonalcoholic steatohepatitis, which is a manifestation of the metabolic syndrome (MetS). We reported previously that α-t...
Metabolic response to epigallocatechin-3-gallate in relapsing-remitting multiple sclerosis: a randomized clinical trial
energy metabolism epigallocatechin-3-gallate multiple sclerosis sex difference calorimetry microdialysis
2015/1/14
Background: Muscle weakness and fatigue are common symptoms in multiple sclerosis (MS). Green tea catechins such as (−)epigallocatechin-3-gallate (EGCG) are known to improve energy metabolism at...