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2017冷泉港学术会议：真核转录机制（Cold Spring Harbor conference on Mechanisms of Eukaryotic Transcription）
mRNA Translation Regulation
2017/1/19
We are pleased to host the eleventh Cold Spring Harbor meeting on Eukaryotic mRNA Processing, which will begin at 7:30 pm on Tuesday, August 22 and run through lunch on Saturday, August 26, 2017. The ...
Dissecting the cellular and molecular mechanisms mediating neurofibromatosis type 1 related bone defects
Mouse model Osteoclasts Transforming growth factor-beta1
2014/5/21
Skeletal manifestations including short stature, osteoporosis, kyphoscoliosis, and tibial dysplasia cumulatively affect approximately 70% of patients with neurofibromatosis type 1 (NF1). Tibial pseuda...
摘要细胞中不同的mRNA半寿期差异很大，mRNA的稳定性受到多种因素的影响，现在已经发现了许多对mRNA的稳定性有影响的顺式因子和反式因子。大量的研究证明在真核细胞内存在复杂的机制调节mRNA的稳定与降解及其所引起的基因表达。现在可以肯定在真核细胞中至少存在着三种mRNA的降解方式：依赖于脱腺苷酸的降解，无义密码介导的mRNA的降解和核酸内切酶的水解。其中依赖于脱腺苷酸的降解方式是细胞内大多数mR...