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In Silico Target Prediction by Training Naive Bayesian Models on Chemogenomics Databases
Chemogenomics Databases Informatics
2015/5/26
The completion of Human Genome Project is seen as a gateway to the discovery of novel drug targets (Jacoby, Schuffenhauer, & Floersheim, 2003). How much of this information is actually translated into...
A Novel Network Biology Approach To Drug Target Selections
Network Biology Approach Drug Target Selections
2015/5/26
Conventional drug discovery focuses on single protein targets and follows a “sequence,
structure, and function” paradigm for selecting best protein targets to screen lead
chemical compounds. This es...
Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells
apoptosis endocycling cells p53 protein
2015/1/7
Apoptotic cell death is an important response to genotoxic stress that prevents oncogenesis. It is known that tissues can differ in their apoptotic response, but molecular mechanisms are little unders...