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Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
Hydroxychloroquine less toxic derivative chloroquine effective inhibiting SARS-CoV-2 infection vitro
2020/3/18
The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/2019-nCoV) poses a serious threat to global public health and local econom...
Gut Microbiome May Make Chemo Drug Toxic to Patients（图）
Gut Microbiome Chemo Drug Toxic Patients
2017/11/1
Albert Einstein College of Medicine researchers report that the composition of people’s gut bacteria may explain why some of them suffer life-threatening reactions after taking a key drug for treating...
N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts
N-methylpurine DNA glycosylase alkylating agents cancer therapeutics
2014/12/12
Previous studies indicate that overexpression of N-methylpurine DNA glycosylase (MPG) dramatically sensitizes cells to alkylating agent-induced cytotoxicity. We recently demonstrated that this sensiti...
Research discovers non-toxic cancer treatment（图）
cancer treatment The interferon alpha protein
2014/1/23
A University of Queensland researcher is developing a “Trojan horse” non-toxic treatment for human breast cancer.
Toxic Methemoglobinemia Treated with Ascorbic Acid: Case report
Methemoglobinemia Prilocaine Ascorbic Acid
2013/10/9
Methemoglobinemia is a disorder characterized by the presence of a higher than normal level of methemoglobin. Prilocaine which is one of the oxidizing local anaesthetics is widely used in many local p...
THE IMPACT OF TOXIC HEAVY METALS ON THE HEMATOLOGICAL PARAMETERS IN COMMON CARP (CYPRINUS CARPIO L.)
Heavy metals hematology blood glucose common carp Cyprinus carpio L.
2009/12/14
The aim of the present investigation was to determine the effect of heavy metal pollutants such as cadmium, chromium, nickel and lead in aquatic system on common carp (Cyprinus carpio L.) by using a s...
High hydrostatic pressure potentiation of the toxic effects of chromate in cell culture
human chromate cell culture commercial welding
2009/7/14
Development of hyperbaric welding has created the need for new occupational health standards. We have used cell cultures to investigate effects of high pressure chromate on the toxicity of the welding...
Effects of Angiotensin Converting Enzyme Inhibitors in Healthy Rats and in Rats With Carbon Tetrachloride-Induced Toxic Hepatitis
Captopril enalapril carbon tetrachloride hepatotoxicity
2009/6/30
Sulphydryl-containing captopril (CPR) appears to act as a scavanger of oxygen derived free radicals. This is not present in other angiotensin-converting enzymes such as enalapril (EPR). The hepatotoxi...
Investigating Toxic Effects of the HIV-RT Inhibitor 2-Phenoxymethyl-5-Chloro-Benzimidazole on Rat Liver
AIDS HIV-RT inhibitor hepatic toxicity histopathology 2-phenoxymethyl-5-chloro-benzimidazole dimethylsulfoxide
2009/6/23
The aim of this study was to investigate the toxic effects of the human immunodeficiency virus-reverse transcriptase (HIV-RT) inhibitor 2-phenoxymethyl-5-chlorobenzimidazole on rat liver at the light ...
The Status of Trace and Toxic Elements in Biological Samples (Scalp Hair) of Skin-Disease Patients and Normal Subjects
Trace elements toxic elements skin disease scalp hair atomic absorption spectrophotometer
2009/6/19
Background: Direct association of trace and macro-elements in relation to human disease has been observed in many research studies. In many cases, an alteration in the metabolism of these minerals has...
Rapid and Simultaneous Determination of Acetylsalicylic Acid, Paracetamol, and Their Degradation and Toxic Impurity Products by HPLC in Pharmaceutical Dosage Forms
Degradation and impurity products acetylsalicylic acid paracetamol salicylic acid p-chloroacetanilide HPLC
2009/6/16
Aims: Determinations of drug impurity and drug degradation products are very important from both pharmacological and toxicological perspectives. Establishment of monitoring methods for impurities and ...
Lack of toxic side effects in neutrophils following hyperbaric oxygen
Algorithms Human Flow Cytometry Hyperbaric Oxygenation
2009/6/4
Conflicting data have been reported about the impact of repeated HBO2 exposure on the production of superoxide radicals during the neutrophil respiratory burst (RB) and on phagocytosis. In this study ...
Carbon monoxide: From toxic poison to brain messenger
Carbon Monoxide Carbon Monoxide Poisoning Carboxyhaemoglobin haemoproteins lipid peroxidation Cytochrome C surface absorption immune suppression nitric oxide review
2009/5/26
Introduction
Carbon monoxide (CO) is the most common lethal
poison in every community that has been studied.1
Although many of these poisonings are the result of a
deliberate exposure to commit a ...
Toxic fish spine injury: Lessons from 11 years experience
Injury marine animals toxins treatment
2009/5/18
The most important intervention in toxic fish spine
injury is the application of heat. This should be continued
until the pain is relieved and for a minimum of 30 minutes.
Heat treatment applied wi...
Acute toxic effects and kinetics after intravenous injection of cadmium nitrate
cadmium nitrate intravenous injection acute toxicity toxico kinetics
2009/4/1
Cadmium nitrate (CN) is generally used for Ni-Cd batteries in industrial fields. However, there are no reports on the acute lethal toxicity of CN. LD50 and LD90 were 7.2 mg/kg and 8.1 mg/kg, respectiv...