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Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics
A-kinase anchoring protein (AKAP) β-arrestin phosphodiesterase 4 phosphodiesterase inhibitors Src tyrosine kinase
2006/1/19
Cyclic nucleotides are powerful signaling molecules and their sole means of removal is through the action of cyclic nucleotide phosphodiesterases (PDEs). Elevating levels of cAMP is beneficial in many...
The Phosphodiesterase 4 Inhibitor Prevents Antigen-induced Biphasic Nasal Obstruction in Brown Norway Rats
acoustic rhinometry allergic rhinitis BN rat nasal obstruction PDE inhibitor
2005/12/8
Background: Nasal obstruction is considered the most serious problem for patients with allergic rhinitis. We have previously established a model of nasal obstruction in guinea pigs. In the present stu...
Effects of phosphodiesterase inhibitors on secretions of human monokines
cilostazol interleukin-1β KF19514 monocytes phosphodiesterase inhibitor theophylline tumor necrosis factor α
2005/10/14
The purpose of this study was to evaluate the effect of newly developed selective phosphodiesterase (PDE) inhibitors, KF19514 (type I/IV) and cilostazol (type III), and theophylline on the secretions ...