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Implications of Ape1 in reactive oxygen signaling response following cisplatin treatment of dorsal root ganglion neurons
ROS APE1 base excision repair neurotoxicity
2014/12/12
Peripheral neuropathy is one of the major side-effects of the anticancer drug, cisplatin. Although previous work suggests that this neuropathy correlates with formation of DNA adducts in sensory neuro...
siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury
acute kidney injury siRNA
2014/12/11
Proximal tubule cells (PTCs), which are the primary site of kidney injury associated with ischemia or nephrotoxicity, are the site of oligonucleotide reabsorption within the kidney. We exploited this ...
Cisplatin Causes Oxidation in Rat Liver Tissues: Possible Protective Effects of Antioxidant Food Supplementation
Cisplatin hepatotoxicity antioxidant foods protection
2009/6/16
Aims: In this study, we aimed to investigate the possible molecular mechanism of cisplatin hepatotoxicity and to establish whether some natural antioxidant foods, namely dried black grape and tomato, ...