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Synergistic effects of Isatis tinctoria L. and tacrolimus in the prevention of acute heart rejection in mice
satis tinctoria L mice
2013/6/26
Although immunosuppressive treatments are available for acute cardiac rejection no viable treatment exists for long-term cardiac graft failure. Moreover, the extended use of calcineurin inhibitor immu...
Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4(+) memory T cells in mice
Rapamycin tacrolimus rejection
2010/7/28
Donor-reactive memory T (Tm) cells undermine transplanted organs more readily than naive T cells. Rapamycin (RAPA) and tacrolimus (FK-506) are current mainstay immunosuppressants used for preventing a...