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Over time, cancer cells can evolve to become resistant to treatment, more aggressive, and metastatic — capable of spreading to additional sites in the body and forming new tumors. The more of these tr...
Tumor-targeting system uses cancer’s own mechanisms to betray its location
Tumor-targeting system cancer’s own mechanisms betray its location
2017/2/14
By hijacking a cancer cell’s own metabolism, researchers have found a way to tag and target elusive cancers with small-molecule sugars. This opens treatment pathways for cancers that are not responsiv...
Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy
HIF HIF-1α Hypoxia Malignancy Cancer Cancer Therapy
2015/7/28
Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able...
Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
tissue transglutaminase TGF-beta ovarian cancer
2015/5/25
Ovarian cancer (OC) is a lethal disease due to metastasis and chemoresistance. Our laboratory previously reported that tissue transglutaminase (TG2) is overexpressed in OC and enhances OC peritoneal m...
Bone microenvironment and its role in bone metastasis
Bone microenvironment bone metastasis
2015/4/14
Bone is a common site for cancer metastasis. The development of bone metastases represents a serious progression in a patient with cancer, leading to treatment goals changing from curative to palliati...
Tissue banking and its role in clinical and biological advances in oncology
oncology biological advances
2015/4/8
Basic scientific and clinical translational progress in oncology has progressed at an exponential rate over the last 40
years. Much of this progress was germinated in the laboratory, where rigorous ...
Expression of BCL-6 and P-gp in Diffuse Large B-cell Lymphoma and Its Relationship with the IPI Index
弥漫大B细胞淋巴瘤 BCL-6 P-gp IPI指数
2012/6/30
通过免疫组化方法检测初诊弥漫大B细胞淋巴瘤（DLBCL）患者活检淋巴组织BCL-6、P-gp的表达，探讨初诊DLBCL患者上述指标表达的临床意义以及与IPI指数间的相关性。方法：收集福建省立医院病理科存档的2006年10月～2010年10月，首次确诊DLBCL且接受化疗（CHOP或R-CHOP方案）≥2个疗程患者标本34例（其中27例完成6个疗程化疗），检测BCL-6、P-gp的表达。入选病例根据...
Immunohistochemical analysis of P53 and its correlation to the other prognostic factors in breast cancer
p53 immunohistochemistry breast cancer prognostic factor
2010/1/6
Involvement of genetic alterations in breast cancer, one of the most common types of female malignancie, has been well documented . Among the possible alterations, mutations in several genes including...
Sarcomatoid Renal Cell Carcinoma and its Chromophobe Connection
Renal cell carcinoma sarcoma
2009/6/30
Renal cell carcinoma sometimes exhibits sarcomatoid transformation. Sarcomatoid renal cell carcinoma (SRCC) is an uncommon but not rare neoplasm consisting of a typical renal cell carcinoma (RCC) asso...
Bcl - 2 Expression in Carcinoma of the Uterine Cervix and its Relationship with Prognostic Variables
Cervical carcinoma genital tract tumors Bcl-2
2009/6/29
Objective: The aim of this study was to evaluate the importance of the apoptotic activity of squamous cell carcinoma of the cervix and Bcl-2 expression. Materials and Methods: Twenty-seven women with ...
Spirocercosis and its complications in stray dogs in Shiraz, southern Iran
dog esophagus fibrosarcoma Iran
2008/3/17
Spirocerca lupi is accepted in Veterinary Medicine as the cause of true malignancies in dogs. Aortic
lesions and esophageal nodular granulomas are pathological lesions of spirocercosis that are cons...
Combining tumstatin45-132 with tumor necrosis factor-a improves Its antineoplastic activity.
2007/7/28
专著信息
书名
Combining tumstatin45-132 with tumor necrosis factor-a improves Its antineoplastic activity.
语种
英文
撰写或编译
作者
Yi-Qin Luo,Liang-Hua Wang,Yi Qiu,Bing-Hua Jiao
第一作者单位
出版社
Journal of Hepatology, 200...
专著信息
书名
AFP triggers hepatoma cells escaping from immune surveillance through altering the expression of Fas/FasL and tumor necrosis factor related apoptosis-inducing ligand and its receptor of lympho...
期刊信息
篇名
An antisense oligodeoxynucleotide-doxorubicin conjugate: Preparation and its reversal multidrug resistance of human carcinoma cell line in vitro.
语种
英文
撰写或编译
作者
任宇红,魏东芝,刘建文,粟武
第一作者单位
刊物名称
Nucl...
Anti-tumor effects of pNEgr-mIL-12 recombinant plasmid induced by X-irradiation and its mechanisms.
2007/7/28
期刊信息
篇名
Anti-tumor effects of pNEgr-mIL-12 recombinant plasmid induced by X-irradiation and its mechanisms.
语种
英文
撰写或编译
撰写
作者
杨英,刘树铮,付士波
第一作者单位
刊物名称
Biomed.Environ. Sci.
页面
2004, 17 (2): 135-143
出版日期
...