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Rock1 Inhibitor Abrogates Chronic Rejection in Rat Cardiac Model System
Chronic Rejection Transplantation ROCK1 RhoA T Cell
2012/11/6
Background: We have shown previously that the abrogation of acute and chronic rejection of rat cardiac allografts occurs through the down-regulation of RhoA pathway and involves the changes in RhoA ki...
Simvastatin inhibits tissue factor and plasminogen activator inhibitor-1 expression of glomerular mesangial cells in hypercholesterolemic rabbits
Simvastatin inhibits tissue factor plasminogen activator inhibitor-1 glomerular mesangial cells
2009/3/2
Tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) activity and/or expression are upregulated in hypercholesterolemia. Despite extensive research on anti-thrombotic effect of statins, ...
Effect of a neuraminidase inhibitor（oseltamivir）on mouse jump-down behavior via stimulation of dopamine receptors
neuraminidase inhibitor mouse jump-down behavior stimulation of dopamine receptors
2009/3/2
Oseltamivir (Tamiflu®, Roche Laboratories, Inc.) is a neuraminidase inhibitor that can cause jumpdown behaviors in children. There is a mouse slip-down model, in which the dopamine D2 receptor a...
Volumetric Changes in the Components of Left Ventricle Myocardium of Spontaneously Hypertensive Rats Following Exercise and ACE Inhibitor Treatment
hypertrophy ACE-inhibitor volume fraction exercise
2008/4/24
This study was designed to test the possible effects of a combination of physical
and pharmacological therapy intervention on myocardial structure of the left
ventricle in spontaneously hypert...